| Player | Team vs. Opponent | Comp-Att-Yards | TDs | INTs |
| Matt Cassel | New England vs. Ny Jets | 30-51-400 | 3 | 0 |
| Kurt Warner | Arizona vs. Seattle | 32-44-395 | 1 | 1 |
| Donovan McNabb | Philadelphia vs. Cincinnati | 28-58-339 | 1 | 3 |
| Peyton Manning | Indianapolis vs. Houston | 30-46-320 | 2 | 0 |
| Ben Roethlisberger | Pittsburgh vs. San Diego | 31-41-308 | 0 | 0 |
| Marc Bulger | St Louis vs. San Francisco | 34-53-295 | 1 | 2 |
| Drew Brees | New Orleans vs. Kansas City | 25-36-266 | 1 | 1 |
| Ryan Fitzpatrick | Cincinnati vs. Philadelphia | 29-44-261 | 1 | 0 |
| Brett Favre | Ny Jets vs. New England | 26-33-258 | 2 | 0 |
| Jeff Garcia | Tampa Bay vs. Minnesota | 23-30-255 | 0 | 0 |
| Matt Ryan | Atlanta vs. Denver | 20-33-250 | 0 | 1 |
| Tyler Thigpen | Kansas City vs. New Orleans | 19-38-235 | 2 | 1 |
| Kerry Collins | Tennessee vs. Jacksonville | 13-23-230 | 3 | 1 |
| Aaron Rodgers | Green Bay vs. Chicago | 23-30-227 | 2 | 1 |
| Jay Cutler | Denver vs. Atlanta | 19-27-216 | 1 | 0 |
| Shaun Hill | San Francisco vs. St Louis | 15-20-213 | 2 | 0 |
| Daunte Culpepper | Detroit vs. Carolina | 20-35-207 | 1 | 2 |
| Tony Romo | Dallas vs. Washington | 19-27-198 | 1 | 2 |
| Sage Rosenfels | Houston vs. Indianapolis | 13-18-192 | 0 | 1 |
| Brady Quinn | Cleveland vs. Buffalo | 14-36-185 | 0 | 0 |
| Chad Pennington | Miami vs. Oakland | 16-22-174 | 0 | 0 |
| Matt Hasselbeck | Seattle vs. Arizona | 17-29-170 | 1 | 3 |
| Joe Flacco | Baltimore vs. Ny Giants | 20-33-164 | 1 | 2 |
| Philip Rivers | San Diego vs. Pittsburgh | 15-26-164 | 0 | 2 |
| Jason Campbell | Washington vs. Dallas | 22-34-162 | 1 | 1 |
| JaMarcus Russell | Oakland vs. Miami | 15-22-156 | 0 | 0 |
| Eli Manning | Ny Giants vs. Baltimore | 13-23-153 | 1 | 1 |
| Trent Edwards | Buffalo vs. Cleveland | 16-26-148 | 1 | 3 |
| Gus Frerotte | Minnesota vs. Tampa Bay | 14-20-138 | 1 | 0 |
| David Garrard | Jacksonville vs. Tennessee | 13-30-135 | 0 | 1 |
| Kyle Orton | Chicago vs. Green Bay | 13-26-133 | 0 | 0 |
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